D4.3 Direct and Indirect Comparisons

This EUnetHTA 21 deliverable (D4.3) focusses on the methods for treatment comparisons. The objective of this deliverable is to:

• Produce a practical guideline (D4.3.1) on how to deal in practice with direct and indirect comparisons in reports (and which data/documents should then be requested from the HTD).
• Update of existing EUnetHTA guideline (D4.3.2) “Comparators & Comparisons: Direct and indirect comparisons”.
• Check the existing EUnetHTA SOPs for consistency with the practical guideline and the updated EUnetHTA guideline on indirect comparisons; updates will be considered (D4.3.3)*.

Please note that SOPs are considered internal documents and therefore will not be made publicly available. 

D4.3.1 Practical Guideline Direct and Indirect Comparisons 

Below you can find the published documentation: 

 D4.3.2 Methodological Guideline on direct and indirect comparisons

The deliverable D4.3.2 Methodological Guideline on direct and indirect comparisons is now finalized.

This EUnetHTA 21 deliverable (D4.3.2) focusses on the methodological guidance for assessing the results of evidence synthesis in joint clinical assessments (JCAs).
The objectives of this deliverable are to:

• describe the methods currently available for direct and indirect treatment comparisons regarding their underlying assumptions, strengths and weakness
• update of existing EUnetHTA guideline on direct and indirect comparisons (2015).

Below you can find the published documentation: 

For any questions regarding this deliverable, please contact JCA_Secretariat@zinl.nl 

*A minor format update has been conducted on the 01/08/2022.