This document aims to help HTA authors/systematic reviewers define more specific recommendations for Additional Evidence Generation (AEG) – primary research arising from HTA.
It provides a graphical approach for the identification of research gaps arising from HTA reports, and structures the formulation of subsequent research recommendations. Both real life uncertainties and those related to the technology’s clinical effectiveness/safety are addressed in the paper.
The paper does not address prioritization of health technologies that should undergo an HTA process, nor prioritization of research recommendations between different intended uses of a technology or between technologies competing for health systems’ resources.
