The EUnetHTA Joint Action 2 Grant Agreement has been signed by the EU Executive Agency for Health and Consumers and the Coordinator (Danish Health and Medicines Authority) on behalf of 37 partners in 26 EU Member States, Croatia and Norway to start its activities on October 1, 2012. For the next 3 years EUnetHTA will focus on strengthening the practical application of tools and approaches to cross-border HTA collaboration bringing it to a higher level of understanding (both for the Commission and the EU Member States) of ways to establish a sustainable structure for HTA work in the EU. This Technical Annex EUnetHTA JA2 Grant Agreement will further present the target groups, the method and means and the expected outcome of the Joint Action 2 of EUnetHTA.